Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects

  • Constantinides P
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Abstract

PURPOSE: This review highlights the state-of-the-art in pharmaceutical microemulsions with emphasis on self-emulsifying systems, from both a physical and biopharmaceutical perspective. Although these systems have several pharmaceutical applications, this review is primarily focused on their potential for oral drug delivery and intestinal absorption improvement.

METHODS: Physicochemical characteristics and formulation design based on drug solubility and membrane permeability are discussed.

RESULTS: Case studies in which lipid microemulsions have successfully been used to improve drug solubilization/dissolution and/or intestinal absorption of poorly absorbed drugs/peptides are presented.

CONCLUSIONS: Drug development issues such as commercial viability, mechanisms involved, range of applicability, safety, scale-up and manufacture are outlined, and future research and development efforts to address these issues are discussed.

Author-supplied keywords

  • drug dissolution
  • enhancer
  • intestinal absorption
  • medium-chain glycerides
  • membrane permeability
  • microemulsions
  • peptide delivery
  • self-emulsifying systems

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Authors

  • Panayiotis P. Constantinides

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