Skip to content
Journal article

Liposome destabilization induced by the HIV-1 fusion peptide Effect of a single amino acid substitution

Pereira F, Goñi F, Nieva J...(+3 more)

FEBS Letters, vol. 362, issue 2 (1995) pp. 243-246

  • 10

    Readers

    Mendeley users who have this article in their library.
  • 73

    Citations

    Citations of this article.
  • 256

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V ??? E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated ?? conformation. ?? 1995.

Author-supplied keywords

  • Fusion peptide
  • HIV-1
  • Membrane fusion
  • Peptide conformation

Find this document

Get full text

Cite this document

Choose a citation style from the tabs below