Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa

  • Kumar A
  • Kolar S
  • Zao M
 et al. 
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Abstract

Antimicrobial peptide IG-25 (a truncated version of LL-37 of the cathelicidin family) tethering an azido-capped poly(ethylene glycol) chain at the N-terminus was site-specifically attached to alkynyl-terminated polymerized liposomes using copper catalyzed "click" reaction, leading to an 18 fold enhancement in efficacy against Pseudomonas aeruginosa when compared to LL-37 without any increase in cytotoxicity to human corneal epithelial cells.

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Authors

  • Amit Kumar

  • Satya S. Kolar

  • Meriong Zao

  • Alison M. McDermott

  • Chengzhi Cai

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