Locally delivered antimicrobials in periodontal therapy

  • Greene P
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The rapid growth in our understanding of the pathogenesis of periodontal disease has led to a change in therapeutic emphasis, supplementing traditional, non-specific, mechanical plaque control with a more focused targeting of pathogenic organisms. New topical preparations provide high antimicrobial doses at diseased sites without the systemic antibiotic loading which is now, in itself, a cause of concern due to the increasing tendency of micro-organisms to become resistant to antimicrobial agents. This article reviews the current methods of delivering antimicrobial agents to the gingival crevice and evaluates their roles in practical periodontal therapy.

Author-supplied keywords

  • Administration, Topical
  • Anti-Bacterial Agents/*administration & dosage
  • Anti-Infective Agents, Local/administration & dosa
  • Antitrichomonal Agents/administration & dosage
  • Chlorhexidine/administration & dosage
  • Drug Delivery Systems
  • Gels
  • Humans
  • Metronidazole/administration & dosage
  • Periodontal Diseases/*drug therapy
  • Periodontal Pocket/drug therapy
  • Tetracyclines

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  • P R Greene

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