Longitudinal courses of thought disorder in schizophrenia and schizoaffective disorder

  • Marengo J
  • Harrow M
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Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA This research examined the longitudinal courses of thought disorder inschizophrenia, schizoaffective disorder, and other psychotic and nonpsychoticdisorders. One-hundred-eighty young psychiatric inpatients were prospectivelydiagnosed at an early stage of illness and followed up and evaluated forthought disorder at 2, 4.5, and 7.5 years post-index hospitalization. Patternsof thought disorder were examined in relation to diagnosis, index thoughtdisorder, demographic characteristics, prognostic factors, clinical states ofpsychosis, outcome at followup, and treatment. Courses of frequent andpersistent thought disorder were most frequently found in schizophrenia. Theprevalence and course of thought disorder over time in schizoaffective disorderlaid between those in schizophrenia and those in other psychotic disorders.Demographic factors were not predictive of the course of thought disorder.Diagnosis, the presence of thought disorder at index, pre-index work andacademic competence, and pre-index social functioning were associated withcourses of thought disorder (when courses were classified asremitted/infrequent and frequent/persistent). The longitudinal relationshipsbetween thought disorder and psychosis suggested that, in schizophrenia,thought disorder is not simply a function of psychosis. Thought disorderappeared more closely tied to the presence of psychosis over time inschizoaffective disorder. Increased inquiry into the factors associated withdifferent courses of thought disorder across psychiatric disturbances appearsmerited

Author-supplied keywords

  • Adult
  • Cognition Disorders diagnosis
  • Diagnosis
  • Hospitalization
  • Inpatients
  • Prevalence
  • Psychiatry
  • Psychosis
  • Research
  • Schizophrenia
  • Schizophrenia complications
  • Thought disorder
  • Treatment

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  • J T Marengo

  • M Harrow

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