A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses

  • Djuardi Y
  • Sartono E
  • Wibowo H
 et al. 
  • 9

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4 years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-alpha production whereas some alterations in general adaptive immune responses to PHA were observed.

Author-supplied keywords

  • Adaptive Immunity/*immunology
  • Adult
  • BCG Vaccine/administration & dosage/immunology
  • Child, Preschool
  • Female
  • Humans
  • Immunity, Innate/*immunology
  • Indonesia
  • Infant
  • Infant, Newborn
  • Interferon-gamma/immunology/metabolism
  • Interleukin-10/immunology/metabolism
  • Lipopolysaccharides/immunology
  • Longitudinal Studies
  • Male
  • Mycobacterium bovis/immunology
  • Pregnancy
  • Pregnancy Complications, Parasitic/immunology
  • Th1 Cells/immunology/metabolism
  • Th2 Cells/immunology/metabolism
  • Time Factors
  • Tuberculin/immunology
  • Tuberculosis/*immunology/prevention & control
  • Tumor Necrosis Factor-alpha/immunology/metabolism
  • Vaccination/methods

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Y Djuardi

  • E Sartono

  • H Wibowo

  • T Supali

  • M Yazdanbakhsh

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free