Long-Term Leisure-Time Physical Activity and Serum Metabolome.

  • Kujala U
  • Mäkinen V
  • Heinonen I
 et al. 
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Abstract

BACKGROUND: Long-term physical inactivity seems to cause many health problems. We studied whether persistent physical activity compared to inactivity has a global effect on serum metabolome towards reduced cardio-metabolic disease risk. METHODS AND RESULTS: Sixteen same-sex twin pairs (mean age 60 yrs) were selected from a cohort of twin pairs on the basis of their over 30-year discordance for physical activity. Persistently (≥5 years) active and inactive groups in three population-based cohorts (mean ages 31 to 52 years) were also studied (1037 age- and sex-matched pairs). Serum metabolome was quantified by nuclear magnetic resonance spectroscopy. We used permutation analysis to estimate significance of the multivariate effect combined across all metabolic measures; univariate effects were estimated by paired testing in twins as well as in matched pairs, in the cohorts, and by meta-analysis over all sub-studies. Persistent physical activity was associated with the multivariate metabolic profile in the twins (P=0.003), and a similar pattern was observed in all three population cohorts with differing mean ages. Isoleucine, α1-acid glycoprotein and glucose were lower in the physically active than in the inactive individuals (P

Author-supplied keywords

  • Adolescent
  • Adult
  • Blood Glucose
  • Blood Glucose: metabolism
  • Cohort Studies
  • Dizygotic
  • Fatty Acids
  • Fatty Acids: blood
  • Female
  • Humans
  • Isoleucine
  • Isoleucine: blood
  • Leisure Activities
  • Lipoproteins
  • Lipoproteins: blood
  • Male
  • Metabolome
  • Metabolome: physiology
  • Middle Aged
  • Monozygotic
  • Motor Activity
  • Motor Activity: physiology
  • Twins
  • Young Adult

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Authors

  • Urho M Kujala

  • Ville-Petteri Mäkinen

  • Ilkka Heinonen

  • Pasi Soininen

  • Antti J Kangas

  • Tuija H Leskinen

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