Long-term leisure-time physical activity and serum metabolome.

  • Kujala U
  • Makinen V
  • Heinonen I
 et al. 
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BACKGROUND: Long-term physical inactivity seems to cause many health problems. We studied whether persistent physical activity compared with inactivity has a global effect on serum metabolome toward reduced cardiometabolic disease risk. METHODS AND RESULTS: Sixteen same-sex twin pairs (mean age, 60 years) were selected from a cohort of twin pairs on the basis of their >30-year discordance for physical activity. Persistently (>/=5 years) active and inactive groups in 3 population-based cohorts (mean ages, 31-52 years) were also studied (1037 age- and sex-matched pairs). Serum metabolome was quantified by nuclear magnetic resonance spectroscopy. We used permutation analysis to estimate the significance of the multivariate effect combined across all metabolic measures; univariate effects were estimated by paired testing in twins and in matched pairs in the cohorts, and by meta-analysis over all substudies. Persistent physical activity was associated with the multivariate metabolic profile in the twins (P=0.003), and a similar pattern was observed in all 3 population cohorts with differing mean ages. Isoleucine, alpha1-acid glycoprotein, and glucose were lower in the physically active than in the inactive individuals (P

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  • Urho M Kujala

  • Ville-Petteri Makinen

  • Ilkka Heinonen

  • Pasi Soininen

  • Antti J Kangas

  • Tuija H Leskinen

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