Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity

  • Irvine D
  • Stachowiak A
  • Hori Y
  • 71

    Readers

    Mendeley users who have this article in their library.
  • 21

    Citations

    Citations of this article.

Abstract

The plasticity of the immune system is evident in the reorganization of secondary lymphoid organs during immune responses, lymphoid tissue neogenesis occurring during chronic inflammation or graft rejection, and the engineered lymphoid tissue formation induced by ectopic expression of single lymphoid tissue-associated genes. Approaches seeking to harness this plasticity for immunotherapy are under investigation, particularly by controlling immune cell recruitment and lymphoid tissue formation at tumor sites. By combining strategies from ectopic tissue induction models with methods from tissue engineering, new approaches for studying lymphoid tissue development and immunotherapy may be possible. © 2007.

Author-supplied keywords

  • Homeostatic chemokines
  • Lymphoid tissue neogenesis
  • Lymphotoxin
  • Tertiary lymphoid tissues
  • Tissue engineering

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free