Background: The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo. Objective: To determine whether different pathologic substrates of FTD have distinct patterns of regional atrophy on magnetic resonance imaging (MRI). Design: Retrospective case study. Setting: The Institute of Neurology, University College London, and the Institute of Psychiatry, King's College London. Patients: Twenty-one cases of FTD selected on pathologic grounds (9 with ubiquitin-positive [tau- and α-synuclein- negative] inclusions [FTD-U], 7 with Pick disease [PiD], and 5 with familial FTD with tau exon 10+16 mutations [tau exon 10+16]) and 20 healthy controls were studied. Main Outcome Measures: Patterns of gray matter atrophy in each group as assessed by voxel-based morphometry (VBM) and a blinded visual assessment of each MRI study. Results: All pathologic substrates were associated with atrophy that involved the inferior and medial temporal and inferior frontal lobes. Additionally, specific VBM signatures were identified for each subgroup: FTD-U was associated with asymmetric (left > right) temporal lobe atrophy, PiD was associated with severe dorsolateral bifrontal atrophy, and tau exon 10+16 was associated with asymmetric (right>left) medial temporal lobe atrophy. The VBM findings were supported by blinded visual assessment. Conclusion: These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD. ©2005 American Medical Association. All rights reserved.
CITATION STYLE
Whitwell, J. L., Josephs, K. A., Rossor, M. N., Stevens, J. M., Revesz, T., Holton, J. L., … Warren, J. D. (2005). Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia. Archives of Neurology, 62(9), 1402–1408. https://doi.org/10.1001/archneur.62.9.1402
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