Magnetic Resonance-Guided Drug Delivery

  • Mikhail A
  • Partanen A
  • Yarmolenko P
 et al. 
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Abstract

The use of clinical imaging modalities for the guidance of targeted drug delivery systems, known as image-guided drug delivery (IGDD), has emerged as a promising strategy for enhancing antitumor efficacy. MR imaging is particularly well suited for IGDD applications because of its ability to acquire images and quantitative measurements with high spatiotemporal resolution. The goal of IGDD strategies is to improve treatment outcomes by facilitating planning, real-time guidance, and personalization of pharmacologic interventions. This article reviews basic principles of targeted drug delivery and highlights the current status, emerging applications, and future paradigms of MR-guided drug delivery.

Author-supplied keywords

  • Cancer
  • Drug delivery
  • High-intensity focused ultrasound
  • Imaging guidance
  • MR imaging
  • Nanomedicine
  • Thermosensitive liposome
  • Tumor targeting

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Authors

  • Andrew MikhailNational Institutes of Health Clinical Center

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  • Ari Partanen

  • Pavel Yarmolenko

  • Aradhana M. Venkatesan

  • Bradford J. Wood

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