Magnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements

  • Ridha B
  • Symms M
  • Tozer D
 et al. 
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Abstract

BACKGROUND AND PURPOSE: Alzheimer disease (AD) is accompanied by macroscopic atrophy on volumetric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects. MATERIALS AND METHODS: Volumetric T1-weighted images and 3D MTR maps were obtained from 18 patients with AD and 18 age-matched control subjects. Whole-brain (WB) and total hippocampal (Hc) volumes were measured using semiautomated techniques and adjusted for total intracranial volume. Mean MTR was obtained for WB and in the Hc region. Histogram analysis was performed for WB MTR. Among patients, associations between volumetric and MTR parameters and the Mini-Mental State Examination (MMSE) were explored. RESULTS: Patients with AD had significantly reduced WB volume (P

Author-supplied keywords

  • *Magnetic Resonance Imaging
  • Aged
  • Alzheimer Disease/*pathology
  • Atrophy
  • Brain/*pathology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sensitivity and Specificity

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Authors

  • B H Ridha

  • M R Symms

  • D J Tozer

  • K C Stockton

  • C Frost

  • M M Siddique

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