A major zebrafish polymorphism resource for genetic mapping

  • Bradley K
  • Bradford J
  • Breyer J
 et al. 
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Abstract

We have identified 645,088 candidate polymorphisms in zebrafish and observe a single nucleotide polymorphism (SNP) validation rate of 71% to 86%, improving with polymorphism confidence score. Variant sites are non-random, with an excess of specific novel T- and A-rich motifs. We positioned half of the polymorphisms on zebrafish genetic and physical maps as a resource for positional cloning. We further demonstrate bulked segregant analysis using the anchored SNPs as a method for high-throughput genetic mapping in zebrafish.

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Authors

  • Kevin M. Bradley

  • J. Bradford Bradford

  • Joan P. Breyer

  • Brian L. Yaspan

  • Jason R. Jessen

  • Ela W. Knapik

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