Male pattern baldness and coronary heart disease: the Physicians' Health Study

  • Lotufo P
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OBJECTIVE: To confirm the association between male pattern baldness and coronary heart disease (CHD). DESIGN: Meta-analysis of observational studies. DATA SOURCES: Medline and the Cochrane Library were searched for articles published up to November 2012 using keywords that included both 'baldness' and 'coronary heart disease' and the reference lists of those studies identified were also searched. STUDY SELECTION: Observational studies were identified that reported risk estimates for CHD related to baldness. Two observers independently assessed eligibility, extracted data and assessed the possibility of bias. DATA SYNTHESIS: The adjusted relative risk (RR) and 95% CI were estimated using the DerSimonian-Laird random-effect model. RESULTS: 850 possible studies, 3 cohort studies and 3 case-control studies were selected (36 990 participants). In the cohort studies, the adjusted RR of men with severe baldness for CHD was 1.32 (95% CI 1.08 to 1.63, p=0.008, I(2)=25%) compared to those without baldness. Analysis of younger men (

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  • Pa Lotufo

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