The mammalian circadian clock

  • Albrecht U
  • Eichele G
  • 4


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Organisms populating the earth are under the steady influence of daily and seasonal changes resulting from the planet's rotation and orbit around the sun. This periodic pattern most prominently manifested by the light-dark cycle has led to the establishment of endogenous circadian timing systems that synchronize biological functions to the environment. The mammalian circadian system is composed of many individual, tissue-specific clocks. To generate coherent physiological and behavioral responses, the phases of this multitude of clocks are orchestrated by the master circadian pacemaker residing in the suprachiasmatic nuclei of the brain. Genetic, biochemical and genomic approaches have led to major advances in understanding the molecular and cellular basis of mammalian circadian clock components and mechanisms.

Author-supplied keywords

  • Animals
  • Cell Cycle Proteins
  • Chronobiology Disorders
  • Circadian Rhythm
  • Gene Expression Profiling
  • Humans
  • Mice
  • Nuclear Proteins
  • Period Circadian Proteins
  • Suprachiasmatic Nucleus

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • U Albrecht

  • G Eichele

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free