Mammalian DNA methyltransferases: a structural perspective.

  • Cheng X
  • Blumenthal R
  • 73


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been recognized to play a major role in controlling gene expression, among other functions. Given their importance, it is surprising how many basic questions remain to be answered about the proteins responsible for this methylation and for coordination with the parallel chromatin-marking system that operates at the level of histone modification. This article reviews recent studies on, and discusses the resulting biochemical and structural insights into, the DNA nucleotide methyltransferase (Dnmt) proteins 1, 3a, 3a2, 3b, and 3L.

Author-supplied keywords

  • Amino Acid Sequence
  • Animals
  • CpG Islands
  • CpG Islands: physiology
  • DNA Methylation
  • DNA Modification Methylases
  • DNA Modification Methylases: chemistry
  • Dimerization
  • Humans
  • Mammals
  • Models, Biological
  • Models, Molecular
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Xiaodong Cheng

  • Robert M Blumenthal

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free