Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. Whereas the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme. © 1992.
CITATION STYLE
Fujioka, M. (1992). Mammalian small molecule methyltransferases: Their structural and functional features. International Journal of Biochemistry. https://doi.org/10.1016/0020-711X(92)90287-B
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