The management of fibromyalgia

  • S.G. R
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Abstract

Fibromyalgia is one of a number of overlapping functional somatic syndromes," including irritable bowel syndrome, tension headache, chronic idiopathic lower back pain, chronic fatigue syndrome and others. These conditions affect females more frequently than males and probably share common underlying neurobiological mechanisms, as well as frequent psychological, cognitive and behavioral comorbidities. Since the pain in these conditions is most likely "central" in origin, classes of drugs such as nonsteroidal antiinflammatory drugs (NSAIDs) and opioids, which are quite effective for "peripheral" pain, are relatively ineffective for the pain seen in these syndromes. Instead, tricyclic and other classes of antidepressants, antiseizure drugs and a number of other neuroactive compounds seem to be more effective. In addition, nonpharmacological therapies such as aerobic exercise and cognitive behavioral therapy are quite effective and frequently underutilized in clinical practice. © 2004 Prous Science. All rights reserved.

Author-supplied keywords

  • *fibromyalgia/dt [Drug Therapy]
  • *fibromyalgia/th [Therapy]
  • amitriptyline/cm [Drug Comparison]
  • amitriptyline/ct [Clinical Trial]
  • amitriptyline/dt [Drug Therapy]
  • analgesia
  • anticonvulsive agent/ct [Clinical Trial]
  • anticonvulsive agent/dt [Drug Therapy]
  • behavior therapy
  • chronic fatigue syndrome
  • citalopram/ct [Clinical Trial]
  • citalopram/dt [Drug Therapy]
  • clinical practice
  • clinical trial
  • clomipramine/ct [Clinical Trial]
  • clomipramine/dt [Drug Therapy]
  • cognitive therapy
  • comorbidity
  • cyclobenzaprine/ct [Clinical Trial]
  • cyclobenzaprine/dt [Drug Therapy]
  • dextromethorphan/ct [Clinical Trial]
  • dextromethorphan/dt [Drug Therapy]
  • doxepin/ct [Clinical Trial]
  • doxepin/dt [Drug Therapy]
  • exercise
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  • fluoxetine/ct [Clinical Trial]
  • fluoxetine/dt [Drug Therapy]
  • growth hormone/ct [Clinical Trial]
  • growth hormone/dt [Drug Therapy]
  • human
  • ibuprofen/ct [Clinical Trial]
  • ibuprofen/dt [Drug Therapy]
  • irritable colon
  • ketamine/ct [Clinical Trial]
  • ketamine/dt [Drug Therapy]
  • low back pain
  • milnacipran/ct [Clinical Trial]
  • milnacipran/dt [Drug Therapy]
  • moclobemide/ct [Clinical Trial]
  • moclobemide/dt [Drug Therapy]
  • monoamine oxidase inhibitor/ct [Clinical Trial]
  • monoamine oxidase inhibitor/dt [Drug Therapy]
  • morphine/ct [Clinical Trial]
  • morphine/dt [Drug Therapy]
  • morphine/iv [Intravenous Drug Administration]
  • naproxen/ct [Clinical Trial]
  • naproxen/dt [Drug Therapy]
  • nonsteroid antiinflammatory agent/ct [Clinical Tri
  • nonsteroid antiinflammatory agent/dt [Drug Therapy
  • opiate/ct [Clinical Trial]
  • opiate/dt [Drug Therapy]
  • paroxetine/cm [Drug Comparison]
  • paroxetine/ct [Clinical Trial]
  • paroxetine/dt [Drug Therapy]
  • pirlindole/ct [Clinical Trial]
  • pirlindole/dt [Drug Therapy]
  • pregabalin/ct [Clinical Trial]
  • pregabalin/dt [Drug Therapy]
  • review
  • serotonin uptake inhibitor/cm [Drug Comparison]
  • serotonin uptake inhibitor/ct [Clinical Trial]
  • serotonin uptake inhibitor/dt [Drug Therapy]
  • sertraline/ct [Clinical Trial]
  • sertraline/dt [Drug Therapy]
  • sleep disorder
  • tension headache
  • tramadol/ct [Clinical Trial]
  • tramadol/dt [Drug Therapy]
  • tricyclic antidepressant agent/ct [Clinical Trial]
  • tricyclic antidepressant agent/dt [Drug Therapy]
  • tropisetron/ct [Clinical Trial]
  • tropisetron/dt [Drug Therapy]
  • venlafaxine/ct [Clinical Trial]
  • venlafaxine/dt [Drug Therapy]
  • zolpidem/dt [Drug Therapy]
  • zopiclone/ct [Clinical Trial]
  • zopiclone/dt [Drug Therapy]

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Authors

  • Rao S.G.

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