Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma

  • Wood L
  • Powell H
  • Gibson P
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Abstract

BACKGROUND: Assessment of airway inflammation in asthma is becoming increasingly important, as the inflammatory phenotype underpins the treatment response.

OBJECTIVE: This study aimed to evaluate mannitol as a tool for assessing airway responsiveness and airway inflammation in asthma, compared with hypertonic saline.

METHODS: Fifty-five subjects with stable asthma completed a hypertonic (4.5%) saline challenge and a mannitol challenge at two separate visits, performed 48-72 h apart, in random order.

RESULTS: Induced sputum was obtained from 49 (89%) subjects during the saline challenge and 42 (76%) subjects during the mannitol challenge (P>0.05). There was a significant correlation between the greatest percentage fall in forced expiratory volume in 1 s (FEV(1)) (r=0.6, P
CONCLUSION: We conclude that mannitol can be used to induce good-quality sputum, useful for analysis of inflammatory mediators and for predicting the inflammatory phenotype in asthma.

Author-supplied keywords

  • Airway inflammation
  • Airway responsiveness
  • Asthma
  • Hypertonic saline
  • Inflammatory phenotypes
  • Mannitol

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Authors

  • L. G. Wood

  • H. Powell

  • P. G. Gibson

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