Mass spectrometric analysis of exhaled breath for the identification of volatile organic compound biomarkers in esophageal and gastric adenocarcinoma

  • Kumar S
  • Huang J
  • Abbassi-Ghadi N
 et al. 
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Abstract

Objective: The present study assessed whether exhaled breath analysis using Selected Ion Flow Tube Mass Spectrometry could distinguish esophageal and gastric adenocarcinoma from noncancer controls. Background: The majority of patients with upper gastrointestinal cancer present with advanced disease, resulting in poor long-term survival rates. Novel methods are needed to diagnose potentially curable upper gastrointestinal malignancies. Methods: A Profile-3 Selected Ion Flow Tube Mass Spectrometry instrument was used for analysis of volatile organic compounds (VOCs) within exhaled breath samples. All study participants had undergone upper gastrointestinal endoscopy on the day of breath sampling. Receiver operating characteristic analysis and a diagnostic risk prediction model were used to assess the discriminatory accuracy of the identified VOCs. Results: Exhaled breath samples were analyzed from 81 patients with esophageal (N=48) or gastric adenocarcinoma (N=33) and 129 controls including Barrett's metaplasia (N=16), benign upper gastrointestinal diseases (N=62), or a normal upper gastrointestinal tract (N=51). Twelve VOCs-pentanoic acid, hexanoic acid, phenol, methyl phenol, ethyl phenol, butanal, pentanal, hexanal, heptanal, octanal, nonanal, and decanal-were present at significantly higher concentrations (P

Author-supplied keywords

  • Barrett esophagus
  • Profile-3 SIFT-MS instrument
  • adult
  • aged
  • article
  • benign tumor
  • biological marker
  • breath analysis
  • butyraldehyde
  • cancer risk
  • cancer staging
  • controlled study
  • cresol
  • decanal
  • diagnostic accuracy
  • diagnostic test accuracy study
  • endoscopic echography
  • esophageal adenocarcinoma
  • esophagogastroduodenoscopy
  • ethylphenol
  • expired air
  • female
  • gastrointestinal disease
  • heptanal
  • hexanal
  • hexanoic acid
  • human
  • major clinical study
  • male
  • mass spectrometer
  • mass spectrometry
  • nonanal
  • octanal
  • pentanal
  • phenol
  • prediction
  • priority journal
  • probability
  • risk assessment
  • selected ion flow tube mass spectrometer
  • selected ion flow tube mass spectrometry
  • sensitivity and specificity
  • stomach adenocarcinoma
  • tumor volume
  • unclassified drug
  • upper gastrointestinal tract
  • valeric acid
  • volatile organic compound

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Authors

  • S Kumar

  • J Huang

  • N Abbassi-Ghadi

  • H A MacKenzie

  • K A Veselkov

  • J M Hoare

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