Mathematical model for the cancer stem cell hypothesis

  • Ganguly R
  • Puri I
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This paper looks at a predictive mathematical model based on cell compartment method. Stem cell mutations are extremely important for the development of cancer even in comparison to a similar mutation in early progenitor cells. This model predicts that repeat damage or mutation to mature cells increases cancer risk. The paper contains mathematical representations of regulatory signals, rates of changes in cellular populations, etc.

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