A Maximum Likelihood Method for Detecting Directional Evolution in Protein Sequences and Its Application to Influenza A Virus

  • Pond S
  • Poon A
  • Leigh Brown A
 et al. 
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Abstract

Abstract We develop a model-based phylogenetic maximum likelihood test for evidence of preferential substitution toward a given residue at individual positions of a protein alignment— directional evolution of protein sequences (DEPS). DEPS can identify both the target ...

Author-supplied keywords

  • Co-evolución
  • evolucion patogenesis
  • evolución proteinas
  • seleccion positiva

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Authors

  • S. L. K. Pond

  • A F Y Poon

  • A J Leigh Brown

  • S D W Frost

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