Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae.

  • Preuss M
  • Leonhard K
  • Hell K
 et al. 
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Abstract

The biogenesis of mitochondria requires the integration of many proteins into the inner membrane from the matrix side. The inner membrane protein Oxa1 plays an important role in this process. We identified Mba1 as a second mitochondrial component that is required for efficient protein insertion. Like Oxa1, Mba1 specifically interacts both with mitochondrial translation products and with conservatively sorted, nuclear-encoded proteins during their integration into the inner membrane. Oxa1 and Mba1 overlap in function and substrate specificity, but both can act independently of each other. We conclude that Mba1 is part of the mitochondrial protein export machinery and represents the first component of a novel Oxa1-independent insertion pathway into the mitochondrial inner membrane.

Author-supplied keywords

  • Cell Division
  • Cell Nucleus
  • Cell Nucleus: genetics
  • Electron Transport
  • Electron Transport Complex IV
  • Electron Transport Complex IV: metabolism
  • Electron Transport: genetics
  • Fungal Proteins
  • Fungal Proteins: genetics
  • Fungal Proteins: metabolism
  • Genetic Complementation Test
  • Intracellular Membranes
  • Intracellular Membranes: chemistry
  • Intracellular Membranes: metabolism
  • Membrane Proteins
  • Membrane Proteins: genetics
  • Membrane Proteins: metabolism
  • Mitochondria
  • Mitochondria: chemistry
  • Mitochondria: enzymology
  • Mitochondria: metabolism
  • Mitochondrial Proteins
  • Mutation
  • Mutation: genetics
  • Nuclear Proteins
  • Nuclear Proteins: genetics
  • Nuclear Proteins: metabolism
  • Precipitin Tests
  • Protein Binding
  • Protein Biosynthesis
  • Protein Transport
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae: cytology
  • Saccharomyces cerevisiae: enzymology
  • Saccharomyces cerevisiae: genetics
  • Saccharomyces cerevisiae: metabolism
  • Substrate Specificity

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Authors

  • Marc Preuss

  • K Leonhard

  • Kai Hell

  • R a Stuart

  • W Neupert

  • J M Herrmann

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