Measurement of bone mineral density via light scattering.

  • Ugryumova N
  • Matcher S
  • Attenburrow D
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Abstract

In this study we have investigated the potential of optical techniques
to monitor changes in bone mineral density (BMD) via changes in scattering
coefficient. For each of five bone samples, diffuse reflection and
transmission coefficients were measured over the wavelength range
520-960 nm using an integrating sphere and CCD spectrometer. These
were converted into optical absorption and scattering coefficients
using a Monte Carlo inversion procedure. Measurements were made on
samples immersed in formic acid solution for different lengths of
time in order to investigate the effect of reduction in BMD on the
optical properties. After full demineralization, the optical scattering
coefficient fell by a factor 4. From the observed degree of fluctuation
of the measurements, we estimate that BMD could be measured with
an accuracy of 7% if optical scattering can be measured with an
accuracy of 10%. We also report preliminary measurements of bone
scattering using optical coherence tomography (OCT). An inter-side
variability of 3% is obtained on dry samples with and without overlying
periosteum. These results suggest that minimally invasive techniques
for measuring optical scattering, such as OCT, may have a role in
monitoring regional changes in BMD. This could be an important advance
in our understanding of bone remodelling and its relationship to
osteoarthritis. Both the integrating sphere and OCT measurements
also suggest that light transport in bone is spatially anisotropic.
OCT was used to assess probability of obtaining results in vivo.

Author-supplied keywords

  • Algorithms; Animals; Bone Density; Computer Simula
  • Biological; Reproducibility of Results; Scatterin
  • Optical Coherence
  • Radiation; Sensitivity and Specificity; Spectrum
  • cytology/physiology; Models
  • methods
  • methods; Horses; Metacarpus
  • methods; Tomography

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  • PMID: 15012014

Authors

  • Nadya Ugryumova

  • Stephen John Matcher

  • Don P Attenburrow

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