The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines

  • Hall M
  • Amjadi S
  • Zhang M
 et al. 
  • 40

    Readers

    Mendeley users who have this article in their library.
  • 101

    Citations

    Citations of this article.

Abstract

The reduction potentials, lipophilicities, cellular uptake and cytotoxicity have been examined for two series of platinum(IV) complexes that yield common platinum(II) complexes on reduction: cis-[PtCl4(NH3)2], cis,trans,cis-[PtCl2(OAc)2(NH3)2], cis,trans,cis-[PtCl2(OH)2(NH3)2], [PtCl4(en)], cis,trans-[PtCl2(OAc)2(en)] and cis,trans-[PtCl2(OH)2(en)] (en = ethane-1,2-diamine, OAc = acetate). As previously reported, the reduction occurs most readily when the axial ligand is chloride and least readily when it is hydroxide. The en series of complexes are marginally more lipophilic than their ammine analogues. The presence of axial chloride or acetate ligands results in a slighter higher lipophilicity compared with the platinum(II) analogue whereas hydroxide ligands lead to a substantially lower lipophilicity. The cellular uptake is similar for the platinum(II) species and their analogous tetrachloro complexes, but is substantially lower for the acetato and hydroxo complexes, resulting in a correlation with the reduction potential. The activities are also correlated with the reduction potentials with the tetrachloro complexes being the most active of the platinum(IV) series and the hydroxo being the least active. These results are interpreted in terms of reduction, followed by aquation reducing the amount of efflux from the cells resulting in an increase in net uptake. © 2004 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Anticancer
  • Lipophilicity
  • Platinum uptake

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Matthew D. Hall

  • Shahriar Amjadi

  • Mei Zhang

  • Philip J. Beale

  • Trevor W. Hambley

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free