Mechanisms of Allergic Sensitization to Foods: Bypassing Immune Tolerance Pathways

  • Berin M
  • 24

    Readers

    Mendeley users who have this article in their library.
  • 11

    Citations

    Citations of this article.

Abstract

The default response of the mucosal immune system to antigens derived from food is one of active immune tolerance carried out by regulatory T cells and induced by dendritic cells residing in the intestinal mucosa. This tolerance response must be inhibited or bypassed to generate allergic sensitization in experimental food allergy and this has been achieved by 3 main approaches: genetic modifications, experimental adjuvants, and bypassing oral tolerance by administering the antigen through alternative routes. This article discusses the implications of these approaches for understanding the mechanisms of sensitization to food allergens in human disease. © 2012 Elsevier Inc.

Author-supplied keywords

  • Adjuvant
  • Dendritic cell
  • Epicutaneous
  • ITreg
  • Innate immunity
  • Oral tolerance

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free