Mechanisms of NOD-like receptor-associated inflammasome activation

  • Wen H
  • Miao E
  • Ting J
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Abstract

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs. © 2013 Elsevier Inc.

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Authors

  • Haitao Wen

  • Edward A. Miao

  • Jenny P Y Ting

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