Mechanisms by which thiazolidinediones enhance insulin action

  • Reginato M
  • Lazar M
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Abstract

Thiazolidinediones (TZDs) are an exciting new class of insulin- sensitizing drugs being used currently for the treatment of non-insulin- dependent diabetes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor, peroxisome proliferator-activated receptor γ (PPARγ). PPARγ is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potential explanations for this paradox are discussed in this review.

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Authors

  • Mauricio J. Reginato

  • Mitchell A. Lazar

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