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Journal article

Mechanisms underlying episodic gonadotropin-releasing hormone secretion

Moenter S, DeFazio R, Pitts G, Nunemaker C...(+4 more)

Frontiers in Neuroendocrinology, vol. 24, issue 2 (2003) pp. 79-93

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The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but the cellular mechanisms and network properties generating GnRH pulses are not well understood. We will explore three primary aspects of this intermittent hormonal signal: the source of rhythm(s), the possible mechanisms comprising oscillator(s), and how GnRH neurons are synchronized to produce a pulse of hormone release into the pituitary portal blood. Current knowledge will be reviewed, and hypotheses and working models proposed for future studies. (C) 2003 Elsevier Science (USA). All rights reserved.

Author-supplied keywords

  • burst
  • calcium
  • embryonic olfactory placode
  • endogenous
  • excitatory amino-acids
  • gnrh
  • gnrh neurons
  • green fluorescent protein
  • gt1 cell
  • in-vitro
  • luteinizing-hormone
  • network
  • neuronal cell-line
  • nitric-oxide synthase
  • oscillator
  • pulsatile
  • rat hypothalamic explants
  • rhesus-monkey
  • rhythm
  • synchronize

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