Where does mediator bind in vivo?

  • Fan X
  • Struhl K
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The Mediator complex associates with {RNA} polymerase {(Pol)} {II,} and it is recruited to enhancer regions by activator proteins under appropriate environmental conditions. However, the issue of Mediator association in yeast cells is controversial. Under optimal growth conditions {(YPD} medium), we were unable to detect Mediator at essentially any S. cerevisiae promoter region, including those supporting very high levels of transcription. In contrast, whole genome microarray experiments in synthetic complete {(SC)} medium reported that Mediator associates with many genes at both promoter and coding regions.

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  • Xiaochun Fan

  • Kevin Struhl

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