Meiotic chromosome behavior in spread preparations of yeast

  • Dresser M
  • Giroux C
  • 35


    Mendeley users who have this article in their library.
  • 114


    Citations of this article.


Chromosome behavior in meiosis is well characterized from cytological and genetic descriptions but little is known of the underlying molecular mechanisms, largely because no one experimental system has been developed to support an integrated application of modern cytological, genetic, and molecular biological methods. To combine efficient analyses of meiotic chromosome structure and function in a single organism, we have extended to yeast methods for making spread preparations of nuclei. Features of yeast meiosis that parallel meiosis in large eukaryotes, such as bouquet formation and prophase chromosome condensation that occurs in concert with synaptonemal complex formation, are evident for the first time. The ability to analyze large numbers of nuclei at the light and electron microscopes in preparations amenable to a variety of cytological and immunocytological techniques will facilitate the description of meiosis at the molecular level in yeast.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • M. E. Dresser

  • C. N. Giroux

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free