Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II

  • Wessells H
  • Levine N
  • Hadley M
 et al. 
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Abstract

We review our experience with Melanotan II, a non-selective melanocortin receptor agonist, in human subjects with erectile dysfunction (ED). Melanotan II was administered to 20 men with psychogenic and organic ED using a double-blind placebo-controlled crossover design. Penile rigidity was monitored for 6 h using RigiScan. Level of sexual desire and side effects were reported with a questionnaire. In the absence of sexual stimulation, Melanotan II led to penile erection in 17 of 20 men. Subjects experienced a mean of 41 min Rigiscan tip rigidity>80%. Increased sexual desire was reported after 13/19 (68%) doses of Melanotan II vs 4/21 (19%) of placebo (P

Author-supplied keywords

  • Impotence
  • MSH
  • Penile erection
  • Sex behavior

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Authors

  • H. Wessells

  • N. Levine

  • M. E. Hadley

  • R. Dorr

  • V. Hruby

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