Melatonin suppresses nighttime memory formation in zebrafish

  • Rawashdeh O
  • De Borsetti N
  • Roman G
 et al. 
  • 160


    Mendeley users who have this article in their library.
  • 95


    Citations of this article.


Memory processes are modulated by the biological clock, although the mechanisms are unknown. Here, we report that in the diurnal zebrafish both learning and memory formation of an operant conditioning paradigm occur better during the day than during the night. Melatonin treatment during the day mimics the nighttime suppression of memory formation. Training in constant light improves nighttime memory formation while reducing endogenous melatonin concentrations. Treatment with melatonin receptor antagonists at night dramatically improves memory. Pinealectomy also significantly improves nighttime memory formation. We adduce that melatonin is both sufficient and necessary for poor memory formation during the night.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Gregg RomanUniversity of Mississippi Department of Biology

  • Oliver Rawashdeh

  • Nancy Hernandez De Borsetti

  • Gregory M. Cahill

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free