Meningioma as second malignant neoplasm after oncological treatment during childhood

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Abstract

A total of 38 patients (18 female/20 male) with childhood meningioma were recruited from the German registry HIT-Endo (1989-2009). In 5 cases meningioma occurred as second malignant neoplasm (SMN). Histologies were confirmed by reference assessment in all cases (SMN: 2 WHO I, 1 WHO II, 2 WHO III). The SMNs were diagnosed at a median age of 12.4 years with a median latency of 10.2 years after primary malignancy (PMN; 4 brain tumors, 1 lymphoblastic leukemia; median age at diagnosis 2.7 years). Meningioma occurred as SMN in the irradiated field of PMN (range 12-54 Gy). The outcome after treatment of SMN meningioma (surgery/irradiation) was favorable in terms of psychosocial status and functional capacity in 4 of 5 patients (1 death). We conclude that survivors of childhood cancer who were exposed to radiation therapy at young age harbor the risk of developing meningioma as a SMN at a particularly short latency period in case of high dose exposure. © Springer-Verlag 2012.

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Müller, H. L., Gebhardt, U., Warmuth-Metz, M., Pietsch, T., Sörensen, N., & Kortmann, R. D. (2012). Meningioma as second malignant neoplasm after oncological treatment during childhood. Strahlentherapie Und Onkologie, 188(5), 438–441. https://doi.org/10.1007/s00066-012-0082-7

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