Mesenchymal stem cell mechanics from the attached to the suspended state

  • Maloney J
  • Nikova D
  • Lautenschläger F
 et al. 
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Abstract

Human mesenchymal stem cells (hMSCs) are therapeutically useful cells that are typically expanded in vitro on stiff substrata before reimplantation. Here we explore MSC mechanical and structural changes via atomic force microscopy and optical stretching during extended passaging, and we demonstrate that cytoskeletal organization and mechanical stiffness of attached MSC populations are strongly modulated over

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Authors

  • John M. Maloney

  • Dessy Nikova

  • Franziska Lautenschläger

  • Emer Clarke

  • Robert Langer

  • Jochen Guck

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