Mesial Temporal Lobe Epilepsy: What Have We Learned?

  • Vermoesen K
  • Smolders I
  • Massie A
 et al. 
  • 13

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (>100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy.

Author-supplied keywords

  • AMPA/immunology
  • Acute Disease
  • Adult
  • Amygdala
  • Amygdala: pathology
  • Amygdala: physiology
  • Animal
  • Animal models
  • Animals
  • Anticonvulsants
  • Anticonvulsants/pharmacology
  • Anticonvulsants: therapeutic use
  • Antiepileptic drug
  • Antiepileptic drugs
  • Attaques
  • Autoimmune Diseases/immunology/physiopathology
  • Behavior
  • Behavioral analysis
  • Burden of disease
  • Burden of epilepsy
  • Calcium/physiology
  • Catecholamines/physiology
  • Cell Count
  • Cell Movement
  • Cerebellar Nuclei
  • Cerebellar Nuclei: pathology
  • Child
  • Chronic Disease
  • Classification
  • Classification of Functioning and Disability
  • Convulsants
  • Convulsants: administration & dosage
  • Cyclic pattern
  • DALYs
  • Definition
  • Diazepam
  • Diazepam: therapeutic use
  • Diet treatment
  • Disease Models
  • Dominant
  • Dose-Response Relationship
  • Drug
  • Drug Synergism
  • Electroencephalography
  • Electroencephalography: methods
  • Encephalitis/immunology/physiopathology
  • Endothelin-1
  • Entorhinal cortex
  • Epidemiology
  • Epilepsies
  • Epilepsy
  • Epilepsy/classification/drug therapy/etiology/gene
  • Epilepsy: drug therapy
  • Epilepsy: prevention & control
  • Epileptogenesis
  • Excitatory Amino Acid Antagonists
  • Excitatory Amino Acid Antagonists: therapeutic use
  • Excitotoxicity
  • Excitotoxicité
  • Fasting
  • Fluoresceins
  • Fluorescent Dyes
  • Fluorescent Dyes: analysis
  • Fluorescent Dyes: diagnostic use
  • GABA/drug effects/physiology
  • Gene array
  • Genes
  • Genetic Predisposition to Disease
  • Gliosis
  • Gliosis: pathology
  • Glutamate/drug effects
  • Glutamic Acid/physiology
  • Hamartoma/complications
  • Hippocampal
  • Hippocampal pilocarpine
  • Hippocampal: pathology
  • Hippocampal: physiology
  • Hippocampus
  • Hippocampus: chemistry
  • Hippocampus: drug effects
  • Hippocampus: pathology
  • History
  • Humans
  • Infant
  • Infantile/genetics/physiopathology
  • International League Against Epilepsy
  • Ion Channels/drug effects/genetics/physiology
  • Ischemia
  • Ischémie
  • Kainic Acid
  • Ketamine
  • Ketamine: therapeutic use
  • Ketogenic diet
  • Kindling
  • Lateral fluid-percussion injury
  • Magnetic resonance imaging
  • Male
  • Membrane Potentials
  • Microinjections
  • Mossy Fibers
  • NMDA receptor
  • Neo-Timm
  • Nerve Degeneration
  • Nerve Degeneration: chemically induced
  • Nerve Degeneration: pathology
  • Neural Pathways
  • Neural Pathways: pathology
  • Neural Pathways: physiopathology
  • Neurologic
  • Neurologic: drug effects
  • Neuronal Plasticity
  • Neuronal Plasticity: physiology
  • Neurons
  • Neurons/pathology/physiology
  • Neurons: pathology
  • Newborn
  • Organic Chemicals
  • Organic Chemicals: analysis
  • Organic Chemicals: diagnostic use
  • Partial/etiology/physiopathology
  • Photothrombotic stroke
  • Pilocarpine
  • Pilocarpine: administration & dosage
  • Pilocarpine: pharmacology
  • Pilocarpine: toxicity
  • Potassium/physiology
  • Preschool
  • Prevalence
  • Progression
  • Rats
  • Receptors
  • Recurrence
  • Seizure
  • Seizure clustering
  • Seizures
  • Seizures: etiology
  • Sodium/physiology
  • Spasms
  • Species Specificity
  • Spontaneous recurrent seizures
  • Sprague-Dawley
  • Staining and Labeling
  • Status Epilepticus
  • Status Epilepticus: chemically induced
  • Status Epilepticus: complications
  • Status Epilepticus: drug therapy
  • Status Epilepticus: pathology
  • Status Epilepticus: physiopathology
  • Status Epilepticus: psychology
  • Status epilepticus
  • Stigma
  • Syndrome
  • Temporal Lobe
  • Temporal Lobe/physiopathology
  • Temporal Lobe: chemically induced
  • Temporal Lobe: drug therapy
  • Temporal Lobe: pathology
  • Temporal Lobe: physiopathology
  • Temporal Lobe: psychology
  • Temporal lobe epilepsy
  • Thalamic Diseases/complications
  • Time Factors
  • Traumatic brain injury
  • Treatment gap
  • Unprovoked
  • Video-EEG
  • Video-EEG monitoring
  • Wistar
  • animal models
  • anti-epileptic drugs
  • as symptomatic
  • basic mechanisms
  • character-
  • commission on classifi-
  • cryptogenic
  • discrete lesions
  • ently share common ictogenesis-related
  • epilepsy
  • epileptic disorders due to
  • epileptogene-
  • gamma-Aminobutyric Acid/physiology
  • hippocampal sclerosis
  • ictogenesis
  • istics such as increased
  • lesions are referred to
  • localization-related epilepsies
  • localized structural brain
  • neurochemistry
  • neuronal excitability and
  • pathophysiology
  • secondary
  • sis
  • surgical treatment
  • temporal lobe epilepsy
  • Épilepsie

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Katia Vermoesen

  • Ilse Smolders

  • Ann Massie

  • Yvette Michotte

  • Ralph Clinckers

  • Asla Pitkänen

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free