Metabolic models of selection response

  • Keightley P
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Consequences of directional selection on metabolic flux are explored in models for which variation in flux among individuals is generated by segregation of allelic variants at enzyme activity loci. The pattern of selection response is strongly affected by the presence of genetic dominance and epistasis, which are automatically generated in metabolic systems. The expected magnitudes of dominance and epistasis effects on flux are evaluated. Small differences in enzyme activity generate little dominance, but a null allele will tend to be recessive for the pathway in which it occurs and for metabolically distant pathways. Epistasis is found to be greatest in short pathways in which large differences in enzyme activity occur. Under divergent artificial selection asymmetrical responses can occur due to the presence of directional dominance and epistasis, and lead to departures from the classic infinitesimal model of quantitative genetic variation. The effects of epistasis and dominance are in opposite directions, however, and partially cancel each other out in a diploid population

Author-supplied keywords

  • Alleles
  • Animal
  • Animals
  • Computational Biology
  • Models,Genetic
  • Selection (Genetics)
  • biology
  • enzymes
  • genetics
  • lead
  • metabolism
  • pathways
  • systems

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • P D Keightley

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free