Metabolic regulation of coronary vascular tone: Role of hydrogen peroxide, purinergic components, and angiotensin

  • Kaneshiro T
  • Saitoh S
  • Machii H
 et al. 
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Abstract

Metabolic regulation plays an important role in modifying coronary vascular tone. We hypothesized that hydrogen peroxide, purinergic components, and angiotensin, produced by cardiac myocytes control coronary vascular tone in proportion to metabolism. We measured changes in the diameter of isolated, pressurized coronary arterioles in response to supernatant from isolated cardiac myocytes in rats (stimulated for 20-, 60-, and 120-min at 400. bpm). Changes in the diameter of arterioles were determined under control conditions following treatment of arterioles with an adenosine receptor antagonist, 8-PSPT, a P2Y1 receptor antagonist, MRS-2179, or an angiotensin II receptor antagonist, olmesartan. A supernatant (500μl to a 2. ml bath) from myocytes stimulated for 20-, 60- and 120-min caused graded vasodilation (14.1 ± 0.4, 20.2 ± 1.6, 53.8 ± 6.2%, P

Author-supplied keywords

  • ADP
  • Adenosine
  • Angiotensin
  • Coronary circulation
  • Hydrogen peroxide
  • Metabolic regulation

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Authors

  • Takashi Kaneshiro

  • Shu ichi Saitoh

  • Hirofumi Machii

  • Osamu Yamaguchi

  • Toshiyuki Ishibashi

  • Yukio Maruyama

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