Metabolic syndrome in french HIV-infected patients: Prevalence and predictive factors after 3 years of antiretroviral therapy

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Treatment of HIV infection with highly active antiretroviral therapy can induce metabolic complications and increase the risk of developing the metabolic syndrome (MS). The purpose of this study was to report the prevalence and the risk factors for MS in HIV-infected patients who started highly active antiretroviral therapy (HAART) after 2000. SYMET is a prospective, multicentric, cohort study evaluating the prevalence of MS in 269 patients who had received continuous HAART for 1 to 4 years up to September 2007. MS was defined according to the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) 2005 criteria. Cross-sectional assessment included clinical examination and fasting evaluation of metabolic, inflammatory, and oxidative parameters. Data were analyzed with Chi-square, Student, or Wilcoxon tests. Univariate and multivariate logistic regressions were performed to identify predictive factors for MS. The prevalence of MS was 18.2% after a median duration of HAART of 29.8 months. In multivariate analysis, predictive factors of MS were high non-HDL-cholesterol (OR=1.87; p

Author-supplied keywords

  • C reactive protein
  • France
  • Human immunodeficiency virus infection
  • abacavir
  • adult
  • article
  • cholesterol blood level
  • clinical assessment
  • clinical examination
  • cohort analysis
  • cross-sectional study
  • diet restriction
  • emtricitabine
  • female
  • fosamprenavir
  • hepatitis C
  • high density lipoprotein cholesterol
  • highly active antiretroviral therapy
  • human
  • indinavir
  • lamivudine
  • lopinavir
  • lopinavir plus ritonavir
  • major clinical study
  • male
  • metabolic syndrome X
  • mixed infection
  • prevalence
  • priority journal
  • prospective study
  • protein blood level
  • risk factor
  • ritonavir
  • tenofovir
  • zidovudine

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  • Biron A.

  • Bobin-Dubigeon C.

  • Volteau C.

  • Piroth L.

  • Perré P.

  • Leport C.

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