Metabolism of alkaloids in coffee plants

  • Ashihara H
  • 90


    Mendeley users who have this article in their library.
  • 34


    Citations of this article.


Coffee beans contain two types of alkaloids, caffeine and trigonelline, as major components. This review describes the distribution and metabolism of these compounds. Caffeine is synthesised from xanthosine derived from purine nucleotides. The major biosynthetic route is xanthosine → 7-methylxanthosine → 7-methylxanthine → theobromine → caffeine. Degradation activity of caffeine in coffee plants is very low, but catabolism of theophylline is always present. Theophylline is converted to xanthine, and then enters the conventional purine degradation pathway. A recent development in caffeine research is the successful cloning of genes of N-methyltransferases and characterization of recombinant proteins of these genes. Possible biotechnological applications are discussed briefly. Trigonelline (N-methylnicotinic acid) is synthesised from nicotinic acid derived from nicotinamide adenine nucleotides. Nicotinate N-methyltransferase (trigonelline synthase) activity was detected in coffee plants, but purification of this enzyme or cloning of the genes of this N-methyltransferase has not yet been reported. The degradation activity of trigonelline in coffee plants is extremely low.

Author-supplied keywords

  • Caffeine
  • Coffea
  • Purine alkaloids
  • Pyridine alkaloids
  • Theobromine
  • Trigonelline

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free