Metabolites from an antarctic sponge-associated bacterium, Pseudomonas aeruginosa

  • Jayatilake G
  • Thornton M
  • Leonard A
 et al. 
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Abstract

In an ongoing survey of the bioactive potential of microorganisms associated with marine invertebrates, the culture media of a sponge-associated bacterial strain of Pseudomonas aeruginosa was found to contain metabolites which inhibit the growth of several Gram-positive microorganisms. A series of diketopiperazines (1-6) including a new natural product (6) and two known phenazine alkaloid antibiotics (7 and 8) were isolated from the culture broth of this bacterium.

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Authors

  • Gamini S. Jayatilake

  • Maureen P. Thornton

  • Alan C. Leonard

  • Julia E. Grimwade

  • Bill J. Baker

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