The identification of ligand-binding sites is often the starting point for protein function annotation and structure-based drug design. Many computational methods for the prediction of ligand-binding sites have been developed in recent decades. Here we present a consensus method metaPocket, in which the predicted sites from four methods: LIGSITEcs, PASS, Q-SiteFinder, and SURFNET are combined together to improve the prediction success rate. All these methods are evaluated on two datasets of 48 unbound/bound structures and 210 bound structures. The comparison results show that metaPocket improves the success rate from ∼70 to 75% at the top 1 prediction. MetaPocket is available at http://metapocket.eml.org. © 2009, Mary Ann Liebert, Inc.
CITATION STYLE
Huang, B. (2009). Metapocket: A meta approach to improve protein ligand binding site prediction. OMICS A Journal of Integrative Biology, 13(4), 325–330. https://doi.org/10.1089/omi.2009.0045
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