Metastatic balloon cell malignant melanoma: A case report and literature review

  • Lee L
  • Zhou F
  • Simms A
 et al. 
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A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.

Author-supplied keywords

  • Balloon cell
  • Clear cell tumors
  • Malignant
  • Melanoma

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  • PMID: 21487528
  • PUI: 362826952
  • ISSN: 19362625
  • SGR: 80051651793
  • SCOPUS: 2-s2.0-80051651793


  • Lili Lee

  • Fang Zhou

  • Anthony Simms

  • Rosemary Wieczorek

  • Yanan Fang

  • Antonio Subietas-Mayol

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