Met-enkephalin induces cytolytic processes of apoptotic type in K562 human erythroid leukemia cells

  • Mernenko O
  • Blishchenko E
  • Mirkina I
 et al. 
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Cytolytic activity of Met-enkephalin, an endogenous opioid peptide, was studied within the 10-7-10-17M concentration range in K562 human erythroid leukemia cells. Cytolytic activity was determined by the trypan blue inclusion method after 13, 15 and 18 h of Met-enkephalin co-incubation with target cells. Discrete maxima of cytolytic activity were detected at concentrations of 10-9-10-10, 10-13and 10-15M. Cytolysis was accompanied by internucleosomal DNA fragmentation which is indicative of the mechanism of cell death being apoptosis.

Author-supplied keywords

  • Apoptosis
  • Cytotoxicity
  • Met-enkephalin

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  • Olga A. Mernenko

  • Elena Yu Blishchenko

  • Irina I. Mirkina

  • Andrey A. Karelin

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