Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?: Experience from a tertiary care centre in Mumbai...[corrected] [published erratum appears in J POSTGRAD MED 2012 Apr-Jun;58(2):158]

  • Phakade R
  • Nataraj G
  • Kuyare S
 et al. 
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Abstract

Background: To improve the empiric antimicrobial therapy of community-acquired (CA) skin and soft tissue infections (SSTIs), it is necessary to generate data on the current spectrum and susceptibility profile of associated bacteria. CA methicillin-resistant Staphylococcus aureus (CA MRSA) is increasingly being reported in SSTIs in India and globally. Aims: The present study was undertaken to determine the bacterial profile of CA-SSTIs, to know the contribution of MRSA in these infections, to determine inducible clindamycin resistance in S. aureus and to compare the resistance patterns of isolates from hospital-acquired (HA) SSTIs. Materials and Methods: Eight hundred and twenty patients with CA SSTIs were prospectively studied. Pus samples were cultured and antimicrobial susceptibility pattern determined. Inducible clindamycin resistance was detected by D-test. Laboratory records were analyzed retrospectively to generate data on HA SSTIs. Results: 619 isolates were recovered in CA-SSTIs, of which S. aureus (73%) and Streptococci (12%) were the most common. Pseudomonas aeruginosa (28%) and Acinetobacter spp (18%) were the predominant HA-SSTI pathogens. Susceptibility of CA S. aureus to antibiotics tested was, penicillin (6%), co-trimoxazole (20%), ciprofloxacin (37%), cefazolin (100%), erythromycin (84%), clindamycin (97%), gentamicin (94%) and fusidic acid (95%). No MRSA was found in CA SSTIs whereas 45% of HA S. aureus strains were methicillin-resistant. HA strains demonstrated significantly higher resistance as compared to their CA counterparts (P

Author-supplied keywords

  • Academic Medical Centers
  • Adolescence
  • Adult
  • Chi Square Test
  • Clindamycin
  • Community-Acquired Infections
  • Community-Acquired Infections -- Classification
  • Community-Acquired Infections -- Microbiology
  • Data Analysis Software
  • Female
  • Human
  • India
  • Male
  • Methicillin-Resistant Staphylococcus Aureus
  • Middle Age
  • Prospective Studies
  • Pyoderma
  • Retrospective Design
  • Soft Tissue Infections -- Etiology

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Authors

  • R S Phakade

  • G Nataraj

  • S K Kuyare

  • U S Khopkar

  • P R Mehta

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