Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni

  • Dillon G
  • Feltwell T
  • Skelton J
 et al. 
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The lung schistosomulum of Schistosoma mansoni is a validated target of protective immunity elicited in vaccinated mice. To identify genes expressed at this stage we constructed a microarray, representing 3088 contigs and singlets, with cDNA derived from in vitro cultured larvae and used it to screen RNA from seven life-cycle stages. Clustering of genes by expression profile across the life cycle revealed a number of membrane, membrane-associated and secreted proteins up-regulated at the lung stage, that may represent potential immune targets. Two promising secreted molecules have homology to antigens with vaccine and/or immunomodulatory potential in other helminths. © 2005 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Blood fluke
  • Life cycle
  • Membrane proteins
  • Schistosoma
  • Secretion
  • Transcriptome

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  • Gary P. Dillon

  • Theresa Feltwell

  • Jason P. Skelton

  • Peter D. Ashton

  • Patricia S. Coulson

  • Michael A. Quail

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