Microbial Transformation of Isolongifolen-4-one

  • Choudhary M
  • Musharraf S
  • Khan M
 et al. 
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The microbial transformation of (+)-isolongifolen-4-one (4) by a no. of fungi by means of a std. two-stage fermn. technique afforded (7R)-12-hydroxyisolongifolen-4-one (5), (7S)-13-hydroxyisolongifolen-4-one (6), (11R)-11-hydroxyisolongifolen-4-one (7), (10R)-10-hydroxyisolongifolen-4-one (8), and (9R)-9-hydroxyisolongifolen-4-one (9). All five metabolites were found to be new, and metabolites 6 and 9 showed potent tyrosinase inhibitory activity (Table 1). The metabolites and their derivs. were characterized on the basis of spectroscopic and single-crystal X-ray-diffraction techniques. [on SciFinder(R)]

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