Miglitol may have a blood glucose lowering effect unrelated to inhibition of alpha-glucosidase

  • Joubert P
  • Foukaridis G
  • Bopape M
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Abstract

Miglitol is an alpha-glucosidase inhibitor which lowers blood glucose and insulin concentrations in healthy volunteers after a starch meal. It also lowers blood glucose concentrations after a starch meal in patients with non-insulin-dependent diabetes mellitus, but under these circumstances insulin is unaffected. We have studied the effect of miglitol after a glucose load in six healthy male volunteers. Although one would expect an alpha-glucosidase inhibitor to have no effect on blood glucose concentrations after a glucose load, miglitol produced a significant decrease in blood glucose concentrations after the absorption peak. This could be due to enhancement of insulin effects or to depression of anti-insulin factors.

Author-supplied keywords

  • 1-deoxynojirimycin
  • alpha-glucosidase inhibitors
  • diabetes mellitus
  • miglitol
  • oral hypoglycaemics

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Authors

  • P. H. Joubert

  • G. N. Foukaridis

  • M. L. Bopape

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