Miglitol is an alpha-glucosidase inhibitor which lowers blood glucose and insulin concentrations in healthy volunteers after a starch meal. It also lowers blood glucose concentrations after a starch meal in patients with non-insulin-dependent diabetes mellitus, but under these circumstances insulin is unaffected. We have studied the effect of miglitol after a glucose load in six healthy male volunteers. Although one would expect an alpha-glucosidase inhibitor to have no effect on blood glucose concentrations after a glucose load, miglitol produced a significant decrease in blood glucose concentrations after the absorption peak. This could be due to enhancement of insulin effects or to depression of anti-insulin factors. © 1987 Springer-Verlag.
CITATION STYLE
Joubert, P. H., Foukaridis, G. N., & Bopape, M. L. (1987). Miglitol may have a blood glucose lowering effect unrelated to inhibition of alpha-glucosidase. European Journal of Clinical Pharmacology, 31(6), 723–724. https://doi.org/10.1007/BF00541303
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