A mild chemically cleavable linker system for functional proteomic applications

  • Verhelst S
  • Fonović M
  • Bogyo M
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Abstract

An amicable split: Small-molecule probes can be applied for the enrichment of specific protein targets from a complex proteome. A cleavable linker system, which prevents the release of unwanted, nonspecifically bound proteins, can be used for a very mild and highly selective cleavage of probe-labeled proteins.

Author-supplied keywords

  • Activity-based probes
  • Affinity purification
  • Cleavable linkers
  • Mass spectrometry
  • Proteomics

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Authors

  • S. H L Verhelst

  • Marko Fonović

  • Matthew Bogyo

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