Mild and practical reductions of prochiral ketones to chiral alcohols using the chiral boronic ester TarB-H

  • Eagon S
  • Kim J
  • Singaram B
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Abstract

Chiral alcohols are prepared under mild conditions in high enantiomeric excesses using the tartaric acid derived chiral boronic ester TarB-H. The phenylboronic acid was quantitatively recovered and recycled using a simple extraction with sodium hydroxide and diethyl ether. Aromatic and aliphatic secondary alcohols were prepared in up to 99% ee.

Author-supplied keywords

  • Asymmetric synthesis
  • Boron
  • Chiral alcohols
  • Reductions

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Authors

  • Scott Eagon

  • Jinsoo Kim

  • Bakthan Singaram

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