Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study

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Abstract

Acute renal failure increases risk of death after cardiac surgery. However, it is not known whether more subtle changes in renal function might have an impact on outcome. Thus, the association between small serum creatinine changes after surgery and mortality, independent of other established perioperative risk indicators, was analyzed. In a prospective cohort study in 4118 patients who underwent cardiac and thoracic aortic surgery, the effect of changes in serum creatinine within 48 h postoperatively on 30-d mortality was analyzed. Cox regression was used to correct for various established demographic preoperative risk indicators, intraoperative parameters, and postoperative complications. In the 2441 patients in whom serum creatinine decreased, early mortality was 2.6% in contrast to 8.9% in patients with increased postoperative serum creatinine values. Patients with large decreases (ΔCrea

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Lassnigg, A., Schmidlin, D., Mouhieddine, M., Bachmann, L. M., Druml, W., Bauer, P., & Hiesmayr, M. (2004). Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study. Journal of the American Society of Nephrology, 15(6), 1597–1605. https://doi.org/10.1097/01.ASN.0000130340.93930.DD

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